Pairs of Shoes and Pairs of Chromosomes

Written by Kelly A. Hogan, University of North Carolina at Chapel Hill

When discussing homologous chromosomes and sister chromatids, I often use analogies to shoes or socks. For example, I may have two pairs of the same cute flats, one pair in yellow and one in turquoise. These flats are the same size, same brand, exact same style. The yellow shoes are like sister chromatids to each other, just as the turquoise shoes are sister chomatids with each other. The yellow and turquoise are like homologs to each other. To carry the analogy further, I ask them what a pair of running sneakers might be analogous to. (These would be a completely different chromosome.)